The aim of this investigation was to design and develop a microemulsion formulation of clopidogrel for enhancing its solubility, and hence its oral bioavailability. ENHANCEMENT OF DISSOLUTION OF CLOPIDOGREL MINI-TABLETS IN INTESTINAL FLUIDS WITH THE AID OF IN-SITU ACIDIFYING. The drug has low solubility in biological fluid, lead to the poor bioavailability after oral Aim: This study aims at enhancement of dissolution profile of clopidogrel.
Abstract: Various strategies have been used for improve drug solubility of poorly water soluble drugs. The aim of this study was to increase. SOLUBILITY ENHANCEMENT OF CLOPIDOGREL BISULFATE BY SOLID DISPERSION TECHNIQUE USING CARBOXYMETHYLCELLULOSE SODIUM AND. PDF | Bioavailability is the key determinant of a drug for its therapeutic effectiveness, which in turn depends upon the solubility of that drug in.
Enhanced Solubility and Dissolution Rate of Clopidogrel by Nanosuspension: Formulation via High Pressure Homogenization Technique and. Enhancement of solubility and bioavailability of Clopidogrel by self- nanoemulsifying drug delivery system. International Conference & B2B on Pharma Research. Objective: The present study aims to enhance the dissolution rate of a poorly water-soluble drug, clopidogrel bisulfate by the preparation of the.